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From Molecules to Models: miRNAs and Advanced Human Platforms of Neurodegeneration and Repair in Multiple Sclerosis

Thematic Area:
Therapeutics
Disease Area:
Multiple Sclerosis
Research Focus:
Inflammation
Collaborators:
Academic
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Background

Multiple sclerosis (MS) is a chronic disease that damages the brain and spinal cord by destroying myelin, the protective layer around nerves. Small molecules called microRNAs (miRNAs) regulate inflammation and repair, and human stem-cell–based models, such as those derived from induced pluripotent stem cells (iPSCs), provide a reproducible and more accurate way to study MS, capturing key aspects of the disease that are difficult to explore otherwise.

Research

This review explores how miRNAs may act as biomarkers and therapies in MS, and highlights advanced human models that might help test strategies for brain repair and remyelination.

Potential Impact

Progress in miRNA research and stem cell–based models will deepen our understanding of MS biology, guiding future strategies to enhance brain repair and paving the way for innovative therapies.

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