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The clinical profile of adult-onset idiopathic generalised epilepsy

Thematic Area:
Diagnostics
Disease Area:
Epilepsy
Collaborators:
Clinical
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Background

Idiopathic generalised epilepsies (IGE) typically begin in childhood or adolescence, with adult-onset cases being less common. This study aims to explore the disease course in patients with adult-onset IGE.

Research

This retrospective observational study examined 425 IGE patients, identifying 55 with adult-onset IGE. It analyzed their clinical features, seizure outcomes, the types of antiseizure medications (ASMs) used, and the effectiveness of treatments.

Potential Impact

IGE should be considered as a possible diagnosis in people who first present with convulsive seizures in adulthood, particularly those aged between 18 and 30 years with normal neuroimaging. Adult-onset IGE has a good prognosis overall, with most people becoming seizure-free and only a minority developing drug-resistant epilepsy and requiring polytherapy with ≥2 ASMs.

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