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Effects of ALS-associated 5’tiRNAGly-GCC on the transcriptomic and proteomic profile of primary neurons in vitro

Thematic Area:
DiagnosticsTherapeutics
Disease Area:
Motor Neuron Disease/ ALSNeurodegenerative Disorders
Research Focus:
Non-coding RNAs
Collaborators:
Academic
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Background

tRNA are involved in protein production but also give rise to smaller fragments called tiRNAs. These are generated during cellullar stress conditions.

Research

We show that a specific tiRNA (5’GlyGCC) is more abundant in ALS, and reprograms the function of nerve cells to accommodate stress conditions.

Potential Impact

tiRNAs may be used as therapeutics for ALS and other neurodegenerative disorders.

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