Home•Our Research•Publications•Protective role of Angiogenin in muscle regeneration in amyotrophic lateral sclerosis: Diagnostic and therapeutic implications
Background
Amyotrophic lateral sclerosis (ALS) is a lethal disease affecting motor neurons (MNs). A loss of these neurons causes muscle wasting, but not all patients show the same degree of muscle wasting.
Research
We show that elevated angiogenin levels in skeletal muscle are linked to slower disease progression and enhanced muscle regeneration and vascularization in ALS.
Potential Impact
Angiogenin (and so called ‘tiRNAs’ generated by Angiogenin) may serve as prognostic markers and therapeutic targets for ALS.